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Polyethylene references & PDFs ↓

Publications

448 references · Organized by clinical topic

Explore a topic or search the full library. Papers from all collections appear together. Existing PDF filenames and duplicate copies are retained; new PubMed records link to the indexed article.

Search topics, filenames and original collection names, not the full text of papers.

448 of 448 references

Anatomy & joint-line geometry36 references
Ligaments & soft-tissue balance32 references
Kinematics, gait & knee motion34 references
Patellofemoral joint & trochlear tracking92 references
Implant design & polyethylene geometry40 references
Surgical technique & instrumentation20 references
Component rotation & positioning7 references
Comparative studies33 references
Patient outcomes & recovery25 references
Implant survivorship & complications20 references
General reference & perspectives109 references

Broader reference material and papers whose filenames do not identify a specific subject. Topics are based on available filenames and collection labels, not a full-text review.

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This library includes research articles and supporting reading. Inclusion is not an endorsement of a study’s conclusions; filenames are not verified citations.

Polyethylene

1,876 references · 711 PDF links

Knee insert design: medial congruence, medial stabilization and constraint, with related bearing designs listed separately.

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Collection scope and sources

Imported from the supplied knee insert reference collection, compiled September 11, 2026. Citations and design tags are preserved from that collection. Its search covers PubMed/MEDLINE; categories reflect indexed terms and are not a full-text assessment of each paper.

PDF links open the original publisher or repository locations recorded in the supplied collection, which identifies these papers as open access. Availability is controlled by those sources. References without a downloaded PDF retain their publisher and database links. Inclusion does not establish clinical superiority.

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Presentations and cases

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Selected reading

Medial stabilization.

16 papers on bearing geometry, measured motion, and clinical outcomes. Reviews may include the primary studies listed here.

Motion · Moonot et al. · 2009Tibiofemoral kinematic analysis of knee flexion for a medial pivot knee

Fluoroscopy · 13 patients / 15 knees

Medial-centered motion during lunge and kneeling, with less tibial rotation than reported for native knees.

Small, activity-specific series; no comparative patient-outcome claim.

Read published paper ↗
Outcomes · Scott & Gray · 2022Outcomes are Better With a Medial-Stabilized vs a Posterior-Stabilized Total Knee Implanted With Kinematic Alignment

Randomized trial · 200 patients · KA · 2 years

MS had greater maximum flexion (132° vs 124°) and a higher Forgotten Joint Score (68.3 vs 58.3).

Single center and specific implant systems. Not every enrollee completed every two-year measure; results do not isolate the polyethylene alone.

Read published paper ↗
Motion · Alesi et al. · 2022No kinematical difference between ultra-congruent and medial-congruent total knee arthroplasty when implanted with mechanical alignment

Dynamic RSA · 8 MC / 8 UC · MA

No detected difference in medial-pivot behavior during sit-to-stand; clinical flexion was greater with MC.

Small sample; absence of a detected difference is not proof of equivalence.

Read published paper ↗
Outcomes · Hoskins et al. · 2022Medial Pivot Designs Versus Conventional Bearing Types in Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Systematic review · 8 randomized trials · 725 knees

Pooled MP-versus-PS comparisons found no clear advantage in measured clinical outcomes.

One high-risk-of-bias trial excluded from pooling; insufficient randomized evidence for other bearing comparisons.

Read published paper ↗
Overview · Romano et al. · 2025Medial Congruent and Medial Pivot Inserts in Total Knee Arthroplasty: A Scoping Review

Scoping review · 39 articles · 6,143 TKAs

Generally favorable outcomes with both MC and MP constructs; terminology and surgical approaches vary.

Heterogeneous evidence does not establish equivalence, a universal PCL strategy, or comparative longevity.

Read published paper ↗
Motion · Nelson-Tranum et al. · 2025Implant design may influence knee flexor activation patterns during stair ascent and descent

Biomechanics and EMG · 52 patients · 1 year

Greater medial AP constraint was associated with lower biceps femoris activation during stair tasks.

Muscle activation is not proof of easier stairs, reduced fatigue, or superior patient outcomes.

Read published paper ↗
Outcomes · French et al. · 2020A Single Surgeon Series Comparing the Outcomes of a Cruciate Retaining and Medially Stabilized Total Knee Arthroplasty Using Kinematic Alignment Principles

Prospective comparison · 90 patients · KA · 1 year

Higher FJS and selected quality-of-life scores with MS; most other measures were comparable.

Small, nonrandomized, single-surgeon comparison with short follow-up.

Read published paper ↗
Outcomes · Jones et al. · 2023Better flexion and early recovery with medial-stabilized vs single-radius total knee arthroplasty with kinematic alignment: Two-year clinical results

Retrospective cohort comparison · 210 patients · KA

MS had greater flexion from six months to two years and selected early pain advantages.

Comparison across separate trials, not a direct randomized comparison. The MS cohort overlaps the Scott–Gray trial.

Read published paper ↗
Outcomes · Chang et al. · 2021A Prospective Randomized Controlled Trial Comparing Medial-Pivot versus Posterior-Stabilized Total Knee Arthroplasty

Randomized trial · 88 patients · 2 years

No detected differences in ROM or measured patient-reported outcomes between MP and PS.

Findings apply to the studied devices and follow-up; no significant difference does not establish equivalence.

Read published paper ↗
Motion · Tsubosaka et al. · 2021Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis

Intraoperative comparison · 30 varus OA knees · CR-TKA

MC reduced AP translation under manual stress at 45° compared with CR inserts. Varus–valgus laxity was comparable.

Intraoperative mechanics, not evidence that MC prevents long-term clinical instability.

Read published paper ↗
Motion · Kaneda et al. · 2022Kinematically Aligned Total Knee Arthroplasty Using Medial Pivot Knee Prosthesis Enhances Medial Pivot Motion

Comparative kinematics · 13 knees / 9 patients · 1 year

KA knees showed greater lateral posterior travel and femoral external rotation than MA knees with the studied MP implant.

Exploratory: 8 KA and 5 MA knees. Does not establish clinical superiority.

Read published paper ↗
Outcomes · Tso et al. · 2021Clinical and Patient-Reported Outcomes of Medial Stabilized Versus Non-Medial Stabilized Prostheses in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis

Systematic review · 21 studies / 13 pooled

FJS favored MS by 13.83 points, just below the review’s chosen clinical-importance threshold of 14; other differences were absent or not clinically important.

Thresholds and study populations vary; statistical significance alone is not clinical importance.

Read published paper ↗
Outcomes · Frye et al. · 2021A Medial Congruent Polyethylene Offers Satisfactory Early Outcomes and Patient Satisfaction in Total Knee Arthroplasty

Retrospective cohort · 327 TKAs · 1 year

MC improved selected early pain, FJS, and satisfaction measures; KOOS/PROMIS and MC-versus-PS satisfaction were similar.

Observational, short-term evidence; does not establish a universal satisfaction advantage.

Read published paper ↗
Motion · Schütz et al. · 2019Kinematic Evaluation of the GMK Sphere Implant During Gait Activities: A Dynamic Videofluoroscopy Study

Dynamic fluoroscopy · 3 groups of 10 patients

The studied Sphere construct limited medial AP excursion while permitting lateral travel and axial rotation.

Selected good-outcome patients and specific devices; industry-supported study.

Read published paper ↗
Motion · Delman et al. · 2021The posterolateral upslope of a low-conforming insert blocks the medial pivot during a deep knee bend in TKA: a comparative analysis of two implants with different insert conformities

Bilateral comparison · 25 patients · KA

The medial ball-in-socket/flat lateral construct maintained a medial pivot. A posterolateral upslope was proposed to explain different motion with the low-conforming CR construct.

Different implant systems, PCL management, and follow-up. No difference in median patient-reported outcomes.

Read published paper ↗
Motion · Gray et al. · 2020Comparison of posterior-stabilized, cruciate-retaining, and medial-stabilized knee implant motion during gait

Randomized implant groups · gait imaging · 74 patients

MS showed less AP drawer/paradoxical translation and a medial center of rotation.

All three implant designs still differed from healthy knees. Motion is not a patient-outcome measure.

Read published paper ↗

Implant selection · focused reading

Design differences and clinical outcomes

Ten primary studies selected for the three evidence views. Several also appear in the existing polyethylene library; these are curated comparisons, not ten new independent datasets.

Randomized clinical comparison · Less drawer at 30°; no detected PROM advantage

The Effect of Implant Design on Sagittal Plane Stability: A Randomized Trial of Medial- versus Posterior-Stabilized Total Knee Arthroplasty

Edelstein AI, Bhatt S, Wright-Chisem J, Sullivan R, Beal M, Manning DW.

J Knee Surg · 2020 May

PubMed ↗ · Published article ↗

Medial-stabilized vs posterior-stabilized TKA · 50 patients analyzed (25 per group) · 2 years · KT-1000 arthrometer

Mean sagittal laxity at 30° was 5.6 vs 10.2 mm (P < .0001). At 90°, the difference was not significant (4.1 vs 5.3 mm; P = .14). Standard patient-reported scores did not differ.

Small trial. Laxity at one angle is not a clinical instability rate. Results do not identify a universal stability target or rank current company products.

Randomized groups · in-vivo motion · A medial center of rotation during walking

Comparison of posterior-stabilized, cruciate-retaining, and medial-stabilized knee implant motion during gait

Gray HA, Guan S, Young TJ, Dowsey MM, Choong PF, Pandy MG.

J Orthop Res · 2020 Aug

PubMed ↗ · Published article ↗

MS (26), PS (23), and CR (25) knees · 74 patients · biplane X-ray imaging during a walking cycle

MS showed less AP drawer and paradoxical anterior translation, with a medial rather than lateral center of rotation. All three groups still differed from healthy knees.

Task-specific kinematics do not establish better pain relief, satisfaction, or implant survival. Our model does not replay the measured trajectories.

Laboratory · cadaveric · Geometry changes laxity in a controlled test

Total knee replacement designs have differing stability under novel robotic testing method in vitro

Holthof SR, Nejima S, Rock M, vanArkel RJ, Brivio A, Barrett D, Amis AA.

Knee Surg Sports Traumatol Arthrosc · 2025 Nov

PubMed ↗ · Published article ↗

Modified designs based on ATTUNE MS, Persona MC, and symmetrical Triathlon · 8 cadaveric knees · same bone cuts · robotic loading: 710 N compression and ±90 N drawer

The single-radius symmetrical design had a larger mean AP laxity envelope than the other tested designs and native knees. Rollback did not differ significantly.

DePuy-funded study using modified test implants. This is not a trial of Triathlon MS, a patient-outcome comparison, or a basis for ranking brands.

Clinical · retrospective comparison · Less crepitus in one historical-control study

Femoral Implant Design Modification Decreases the Incidence of Patellar Crepitus in Total Knee Arthroplasty

Martin JR, Jennings JM, Watters TS, Levy DL, McNabb DC, Dennis DA.

J Arthroplasty · 2017 Apr

PubMed ↗ · Published article ↗

ATTUNE PS vs PFC Sigma PS · 728 ATTUNE / 1,165 PFC Sigma participants · minimum 1 year

Crepitus at 2 years was 0.83% with ATTUNE and 9.4% with PFC Sigma (P < .001). Score and motion differences were not clinically meaningful.

Historical controls cannot isolate trochlear geometry from other changes. Crepitus is not the same endpoint as anterior knee pain. This is ATTUNE PS, not ATTUNE MS.

Clinical · retrospective comparison · A second comparison found no pain advantage

Comparison Between the Attune and PFC Sigma in Total Knee Arthroplasty: No Difference in Patellar Clunk and Crepitus or Anterior Knee Pain

Bateman DK, Preston JS, Mennona S, Gui E, Kayiaros S.

Orthopedics · 2020 Nov

PubMed ↗ · Published article ↗

ATTUNE vs PFC Sigma · 103 ATTUNE / 114 PFC Sigma implants · mean 3.2 years

Anterior knee pain occurred in 15.5% vs 9.7% (P = .219). The study also found no significant overall difference in clunk / crepitus.

Single-surgeon series with bearing-subtype differences. A nonsignificant result does not demonstrate equivalence. Do not pool these rates with a different study’s crepitus endpoint.

Randomized clinical comparison · A positive signal with kinematic alignment

Outcomes are Better With a Medial-Stabilized vs a Posterior-Stabilized Total Knee Implanted With Kinematic Alignment

Scott DF, Gray CG.

J Arthroplasty · 2022 Aug

PubMed ↗ · Published article ↗

Medial-stabilized vs posterior-stabilized TKA · both KA · 200 randomized patients (101 MS / 99 PS) · minimum 2 years

Two-year Forgotten Joint Score was 68.3 vs 58.3 (P = .02); maximum flexion was 132° vs 124° (P < .0001), favoring MS.

Single center and specific constructs. Not every participant completed every outcome measure. The comparison does not isolate the insert or establish a class-wide advantage.

Randomized clinical comparison · Another trial found similar patient scores

A Prospective Randomized Controlled Trial Comparing Medial-Pivot versus Posterior-Stabilized Total Knee Arthroplasty

Chang JS, Kayani B, Moriarty PD, Tahmassebi JE, Haddad FS.

J Arthroplasty · 2021 May

PubMed ↗ · Published article ↗

Medial-pivot vs single-radius posterior-stabilized TKA · 88 patients (43 MP / 45 PS) · 2 years

Oxford Knee Score was 42.7 vs 42.3 (P = .18). ROM, WOMAC, and Knee Society scores also showed no significant between-group differences.

Different trial, constructs and outcome instruments. No detected difference is not proof of equivalence. Do not compare the numerical size of OKS and FJS across trials.

Clinical · registry comparison · Similar ten-year survival in one registry

Long-term survivorship of a medial-pivot total knee system compared with other cemented designs in an arthroplasty registry

Bordini B, Ancarani C, Fitch DA.

J Orthop Surg Res · 2016 Apr

PubMed ↗ · Published article ↗

ADVANCE Medial-Pivot vs other cemented TKA designs · 506 ADVANCE / 20,446 comparator knees · mean follow-up 6.6 years · 10-year estimate

Estimated implant survival was 96.3% vs 95.7%; the difference was not statistically significant.

Observational data; one author was affiliated with the manufacturer. Survival concerns revision, not whether the knee feels normal. This older ADVANCE device is not a current-device class benchmark.

Clinical · registry comparison · A registry counterpoint: revision risk varied

Decreased Survival of Medial Pivot Designs Compared with Cruciate-retaining Designs in TKA Without Patellar Resurfacing

Øhrn FD, Gøthesen Ø, Låstad Lygre SH, Peng Y, Lian ØB, Lewis PL, Furnes O, Röhrl SM.

Clin Orthop Relat Res · 2020 Jun

PubMed ↗ · Published article ↗

Five MP brands vs common CR controls · no patellar resurfacing · 6,310 MP / 70,870 CR knees · Australia and Norway · 2005–2017

Adjusted revision hazard was higher for MP in Australia (HR 1.4; 95% CI 1.2–1.7). Norway’s estimate was uncertain (HR 1.5; CI 0.9–2.4). Results differed by brand.

No patellar resurfacing; observational confounding and variable follow-up. Includes GMK Sphere, not SpheriKA. These historical findings cannot rank current MS products.

Clinical · exact-device cohort · SpheriKA: a short-term trochlear-height cohort

Restoration of the trochlear peaks is unnecessary with a kinematic alignment-optimized femoral component as under-stuffing results in equivalent or better patient-reported outcome scores

Howell SM, Zabiba A, Sadoghi P, Nedopil AJ, Hull ML.

Knee Surg Sports Traumatol Arthrosc · 2025 Dec

PubMed ↗ · Published article ↗

Trochlear peak-height subgroups within GMK SpheriKA KA TKA · 115 knees · retrospective cohort · mean 22 months (12–28)

The cohort compared peak under-stuffing greater than 2 mm with restoration within ±2 mm. Several patient scores favored under-stuffing; over-stuffing was too uncommon for analysis.

No competing-implant control or long-term survival comparison. Associations do not prescribe a resection target. Authors disclosed manufacturer consulting, royalties or research support.

Focused PubMed review: 27 September 2026. Not a systematic review. Abstract-level summaries except the laboratory study, SpheriKA cohort and registry papers, for which full text was reviewed; existing Scott and Chang source reviews were retained.

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